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Development of a DNA Vaccine Targeting Human Papillomavirus Type 16 Oncoprotein E6

27 Jul 2004

Abstract excerpt

Human papillomavirus (HPV), particularly type 16 (HPV-16), is present in more than 99% of cervical cancers. The HPV oncoproteins E6 and E7 are constantly expressed and therefore represent ideal targets for HPV vaccine development. We previously developed DNA vaccines encoding calreticulin (CRT) linked to HPV-16 E7 and generated potent E7-specific CD8(+) T-cell immune responses and antitumor effects against an...

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PMID: 15280455
DOI: 10.1128/jvi.78.16.8468-8476.2004

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