Article
The nonessential H2A N-terminal tail can function as an essential charge patch on the H2A.Z variant N-terminal tail.
Molecular and cellular biology - 1 Apr 2003
Ren Qinghu, Gorovsky Martin A
Abstract excerpt
Tetrahymena thermophila cells contain three forms of H2A: major H2A.1 and H2A.2, which make up approximately 80% of total H2A, and a conserved variant, H2A.Z. We showed previously that acetylation of H2A.Z was essential (Q. Ren and M. A. Gorovsky, Mol. Cell 7:1329-1335, 2001). Here we used in vitro mutagenesis of lysine residues, coupled with gene replacement, to identify the sites of acetylation of the...
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