Article
Specific ubiquitin-conjugating enzymes promote degradation of specific nuclear receptor coactivators.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 2003
Yan Feng, Gao Xiuhua, Lonard David M, Nawaz Zafar
Abstract excerpt
Nuclear receptor coactivators (NRCoAs) are nuclear hormone receptor-associated regulatory proteins that interact with members of the nuclear receptor superfamily in the presence of their cognate ligand, enhancing their transcriptional activity. The identification of ubiquitin-proteasome pathway proteins as coactivators provides evidence that ubiquitin-proteasome-mediated protein degradation plays an integral role...
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