Article
The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily.
Molecular and cellular biology - 1 Feb 1999
Nawaz Z, Lonard D M, Smith C L, Lev-Lehman E, Tsai S Y, Tsai M J, O'Malley B W
Abstract excerpt
In this study, we found that the E6-associated protein (E6-AP/UBE3A) directly interacts with and coactivates the transcriptional activity of the human progesterone receptor (PR) in a hormone-dependent manner. E6-AP also coactivates the hormone-dependent transcriptional activities of the other mem...
Topics
- Angelman Syndrome
- Base Sequence
- Binding Sites
- DNA Primers
- HeLa Cells
- Humans
- In Vitro Techniques
- Ligands
- Ligases
- Mutation
- Phenotype
- Receptors, Estrogen
- Receptors, Progesterone
- Receptors, Steroid
- Trans-Activators
- Transcriptional Activation
- Ubiquitin-Protein Ligases