Article
Ligand-dependent degradation of retinoid X receptors does not require transcriptional activity or coactivator interactions.
Molecular and cellular biology - 1 Aug 2001
Osburn D L, Shao G, Seidel H M, Schulman I G
Abstract excerpt
Cells utilize ubiquitin-mediated proteolysis to regulate the activity of numerous proteins involved in signal transduction, cell cycle control, and transcriptional regulation. For a number of transcription factors, there appears to be a direct correlation between transcriptional activity and protein instability, suggesting that cells use targeted destruction as one method to down-regulate or attenuate gene...
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