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Article

UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation.

The Journal of endocrinology - 1 Sept 2006

Garside Helen, Waters Charlotte, Berry Andy, Rice Lisa, Ardley Helen C, White Anne, Robinson Philip A, Ray David

Abstract excerpt

Unlike other nuclear receptors, transactivation by the glucocorticoid receptor (GR) is increased by the inhibition of the ubiquitin/proteasome pathway. Here, we demonstrate that the ubiquitin-conjugating enzyme (E2), UbcH7, physically interacts with the GR and, when overexpressed, reduces the abi...

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Source

Identifiers

PMID: 17003263
DOI: 10.1677/joe.1.06799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17003263-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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