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Article

Cigarette smoking and genetic alterations in sporadic colon carcinomas.

Carcinogenesis - 1 Mar 2003

Diergaarde Brenda, Vrieling Alina, van Kraats Annemieke A, van Muijen Goos N P, Kok Frans J, Kampman Ellen

Abstract excerpt

Cigarette smoking has been inconsistently associated with colon cancer risk. To evaluate the hypothesis that smoking is primarily linked to a specific colon tumor subgroup(s), we assessed associations between smoking and the occurrence of mutations in the APC, K-ras and p53 genes, p53 overexpression, and microsatellite instability (MSI) in a Dutch population-based case-control study on sporadic colon carcinomas....

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Identifiers

PMID: 12663519
DOI: 10.1093/carcin/24.3.565

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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