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Article

Increased frequency of p53 mutation in sporadic colorectal cancer from cigarette smokers.

Japanese journal of clinical oncology - 1 Jun 2002

Miyaki Michiko, Iijima Takeru, Ishii Reiko, Kita Yumi, Koike Morio, Kuroki Toshio, Mori Takeo

Abstract excerpt

BACKGROUND: Cigarette smoking has been shown to increase the risk of colorectal cancer. However, the relation between smoking and genetic alterations has not been clarified in this type of cancer. METHODS: Mutations of p53, APC, beta-catenin and K-ras-2 genes were analyzed in colorectal carcinomas from 28 smokers and 33 non-smokers. Frequencies and types of mutations were compared between smokers and non-smokers....

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Identifiers

PMID: 12110635
DOI: 10.1093/jjco/hyf047

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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