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Article

Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer.

Journal of the National Cancer Institute - 6 Dec 2006

Samowitz Wade S, Albertsen Hans, Sweeney Carol, Herrick Jennifer, Caan Bette J, Anderson Kristin E, Wolff Roger K, Slattery Martha L

Abstract excerpt

BACKGROUND: Cigarette smoking has been associated with microsatellite instability in sporadic colon cancer. Most microsatellite-unstable colon cancers have widespread methylation of CpG islands (i.e., the CpG island methylator phenotype [CIMP]), and many of these tumors harbor the V600E BRAF mutation. We investigated whether the association between smoking and all colon cancers could be explained through...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17148775
DOI: 10.1093/jnci/djj468

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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