Article
p53 over-expression and p53 mutations in colon carcinomas: relation to dietary risk factors.
International journal of cancer - 31 May 1999
Voskuil D W, Kampman E, van Kraats A A, Balder H F, van Muijen G N, Goldbohm R A, van't Veer P
Abstract excerpt
Epidemiological studies have suggested that dietary factors may differently affect p53-dependent and p53-independent pathways to colon cancer. Results of such studies may depend on the method used to assess p53 status. This case-control study of 185 colon-cancer cases and 259 controls examines this relation, using both immunohistochemistry and SSCP(exons 5-8)/sequencing to detect p53 abnormalities. Of 185...
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