Article
XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity.
Carcinogenesis - 1 Mar 2003
Wu Xifeng, Zhao Hua, Wei Qingyi, Amos Christopher I, Zhang Kerang, Guo Zhaozheng, Qiao Yawei, Hong Waun K, Spitz Margaret R
Abstract excerpt
XPA, a DNA binding protein in the nucleotide excision repair (NER) pathway, modulates damage recognition. Recently, a common single-nucleotide polymorphism (A --> G) of unknown function was identified in the 5' non-coding region of the XPA gene. Because a deficiency in NER is associated with an increased risk of lung cancer, we evaluated the role of this polymorphism in 695 lung cancer case patients and 695 age-,...
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