Article
Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients.
Cancer research - 15 Feb 2001
Spitz M R, Wu X, Wang Y, Wang L E, Shete S, Amos C I, Guo Z, Lei L, Mohrenweiser H, Wei Q
Abstract excerpt
Sequence variations have been identified in a number of DNA repair genes, including XPD, but the effect of these polymorphisms on DNA repair capacity (DRC) is uncertain. We therefore examined XPD polymorphisms at Lys751Gln and Asp312Asn in 341 white lung cancer cases and 360 age-, sex-, ethnicity-, and smoking-matched controls accrued in a hospital-based molecular epidemiological study of susceptibility markers...
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