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Article

Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer.

Cancer research - 1 Jan 2013

Wang Li-E, Gorlova Olga Y, Ying Jun, Qiao Yawei, Weng Shih-Feng, Lee Annette T, Gregersen Peter K, Spitz Margaret R, Amos Christopher I, Wei Qingyi

Abstract excerpt

Suboptimal cellular DNA repair capacity (DRC) has been shown to be associated with enhanced cancer risk, but genetic variants affecting the DRC phenotype have not been comprehensively investigated. In this study, with the available DRC phenotype data, we analyzed correlations between the DRC phenotype and genotypes detected by the Illumina 317K platform in 1,774 individuals of European ancestry from a Texas lung...

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Source

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Identifiers

PMID: 23108145
DOI: 10.1158/0008-5472.CAN-12-1915
PMCID: PMC3537906

Genes

DUSP1
ERCC2
PHACTR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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