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Article

Prediction of the association state of insulin using spectral parameters.

Journal of pharmaceutical sciences - 1 Apr 2003

Uversky Vladimir N, Garriques Liza Nielsen, Millett Ian S, Frokjaer Sven, Brange Jens, Doniach Sebastian, Fink Anthony L

Abstract excerpt

Human insulin exists in different association states, from monomer to hexamer, depending on the conditions. In the presence of zinc the "normal" state is a hexamer. The structural properties of 20 variants of human insulin were studied by near-UV circular dichroism, fluorescence spectroscopy, and small-angle X-ray scattering (SAXS). The mutants showed different degrees of association (monomer, dimers, tetramers,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12661070
DOI: 10.1002/jps.10355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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