Article

Zinc Determines Dynamical Properties and Aggregation Kinetics of Human Insulin

2020-07-04

Abstract excerpt

Protein aggregation is a widespread process leading to deleterious consequences in the organism, with amyloid aggregates being important not only in biology but also for drug design and biomaterial production. Insulin is a protein largely used in diabetes treatment and its amyloid aggregation is at the basis of the so-called insulin-derived amyloidosis. Here we uncover the major role of zinc in both insulin dynami...

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Literature Corpus work: 7a30e1be-bf31-54ea-ad6b-03e2f53bd968
DOI: 10.1101/2020.07.02.184903

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