Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular variants and derivatives of insulin for improved glycemic control in diabetes.

Progress in biophysics and molecular biology - 1 Jul 2006

Bhatnagar Sonika, Srivastava Deepa, Jayadev M S K, Dubey A K

Abstract excerpt

Insulin is a historic molecule. It presents many first instances, such as the first protein to be fully sequenced, one of the first proteins to be crystallized in pure form, one among the early proteins whose structure was investigated using X-ray crystallography, the first protein to be chemically synthesized and the first Biotech drug. Therefore, the development of insulin in the early years is intricately...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Diabetes Mellitus
Share to Drug Stability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin

Share to Islets of Langerhans

Share to Protein Conformation

Share to Protein Structure, Quaternary

Source

Identifiers

PMID: 16061274
DOI: 10.1016/j.pbiomolbio.2005.05.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular variants and derivatives of insulin for improved glycemic control in diabetes.PMID 16061274Read ↗

The road to the first, fully active and more stable human insulin variant with an additional disulfide bond.Semantic proximity Read ↗

How Structural Modifications of Insulin Icodec Contributes to Its Prolonged Duration of Action: A Structural and Biophysical PerspectiveSemantic proximity Read ↗

Recombinant DNA Technology in the Treatment of Diabetes: Insulin AnalogsSemantic proximity Read ↗

Designing Insulin Analogues with Lower Binding Affinity to Insulin Receptor than That of Insulin IcodecSemantic proximity Read ↗

Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions.Semantic proximity Read ↗

Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex.Semantic proximity Read ↗

Large Scale Purification and Characterization of A21 Deamidated Variant-Most Prominent Post Translational Modification (PTM) for Insulins Which Is Widely Observed in Insulins Pharmaceutical ManufacturingSemantic proximity Read ↗

Comparative physicochemical and structural characterisation studies establish high Biosimilarity between BGL-ASP and Reference Insulin AspartSemantic proximity Read ↗

Camel milk insuline: Pathophysiological and molecular repositorySemantic proximity Read ↗

Se-Glargine I. Chemical Synthesis of a Basal Insulin Analog Stabilized by an Internal Diselenide BridgeSemantic proximity Read ↗

Four new monomeric insulins obtained by alanine scanning the dimer-forming surface of the insulin molecule.Semantic proximity Read ↗

Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.