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Article

Application of SIMSTEX to oligomerization of insulin analogs and mutants.

Journal of the American Society for Mass Spectrometry - 1 Nov 2006

Chitta Raghu K, Rempel Don L, Grayson Michael A, Remsen Edward E, Gross Michael L

Abstract excerpt

The propensity of various insulins and their analogs to oligomerize was investigated by mass spectrometric methods including measurement of the relative abundances of oligomers in the gas phase and the kinetics of H/D amide exchange. The kinetics of deuterium uptake show a good fit when the exchanging amides are placed in three kinetic groups: fast, intermediate, and slow. r-Human insulin, of the insulins...

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PMID: 16952461
DOI: 10.1016/j.jasms.2006.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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