Article
Estrogen receptor variants ERdelta5 and ERdelta7 down-regulate wild-type estrogen receptor activity.
Molecular and cellular endocrinology - 25 Oct 1999
Wang H, Zeng X, Khan S A
Abstract excerpt
The estrogen receptor (ER) plays a key role in mediating the effect of estrogens. It is the primary target for endocrine therapy for many diseases, including breast cancer. The ER contains six domains that are associated with distinct functions; the presence of all six domains is required for ligand-dependent receptor activity. ER variants, reported in breast tumors and other neoplasms, usually lack one or more...
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