Article
Activity of delafloxacin against methicillin-resistant Staphylococcus aureus: resistance selection and characterization.
The Journal of antimicrobial chemotherapy - 1 Dec 2012
Remy Joan M, Tow-Keogh Cheryl A, McConnell Timothy S, Dalton James M, Devito Joseph A
Abstract excerpt
OBJECTIVES: To determine the potential for delafloxacin to select for resistant mutants in methicillin-resistant Staphylococcus aureus (MRSA), including isolates with existing mutations in the quinolone resistance determining region (QRDR). METHODS: Susceptibility testing by broth microdilution was performed on 30 MRSA clinical isolates. For four of these isolates, the presence or absence of mutations in the QRDR...
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