Staphylococcus aureus mutants selected by BMS-284756.

doi:10.1128/AAC.45.11.3273-3275.2001

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Article

Staphylococcus aureus mutants selected by BMS-284756.

Antimicrobial agents and chemotherapy - 1 Nov 2001

Discotto L F, Lawrence L E, Denbleyker K L, Barrett J F

Abstract excerpt

BMS-284756, a novel des-fluoro(6)-quinolone, was used to select for in vitro mutants of Staphylococcus aureus ISP794. Step mutants were obtained, and the quinolone resistance-determining regions of four target genes, gyrA, gyrB, grlA, and grlB, were sequenced. The data suggest that DNA gyrase is the primary target for BMS-284756 in S. aureus.

Topics

Anti-Infective Agents
Ciprofloxacin
DNA Gyrase
DNA, Bacterial
Drug Resistance, Microbial
Fluoroquinolones
Indoles
Mutation
Quinolones
Reverse Transcriptase Polymerase Chain Reaction
Staphylococcus aureus

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Identifiers

PMID: 11600399
DOI: 10.1128/AAC.45.11.3273-3275.2001
PMCID: PMC90825

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