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Article

Insulin-stimulated cyclic guanosine monophosphate inhibits vascular smooth muscle cell migration by inhibiting Ca/calmodulin-dependent protein kinase II.

Circulation - 25 Mar 2003

Zhang Sui, Yang Yu, Kone Bruce C, Allen Julius C, Kahn Andrew M

Abstract excerpt

BACKGROUND: Insulin resistance is associated with vascular disease. Physiological concentrations of insulin inhibit cultured vascular smooth muscle cell (VSMC) migration in the presence of nitric oxide, and the failure to do so in insulin-resistant states may aggravate vascular disease. We sought to determine the molecular mechanisms by which insulin inhibits VSMC migration. METHODS AND RESULTS: Insulin at 1...

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PMID: 12654613
DOI: 10.1161/01.cir.0000056766.45109.c1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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