Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells.

Abstract excerpt

Insulin-like growth factor-I (IGF-I) plays a role in mutually exclusive processes such as proliferation and differentiation in a variety of cell types. IGF-I is a potent mitogen and motogen for dedifferentiated vascular smooth muscle cells (VSMCs) in vivo and in vitro. However, in differentiated VSMCs, IGF-I is only required for maintaining the differentiated phenotype. Here we investigated the VSMC...

Topics

• Animals
• Cell Division
• Cell Movement
• Dose-Response Relationship, Drug
• Enzyme Activation
• Enzyme Inhibitors
• Flavonoids
• Insulin Receptor Substrate Proteins
• Insulin-Like Growth Factor I
• Intracellular Signaling Peptides and Proteins