Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells.

doi:10.1074/jbc.M109.092270

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Article

Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells.

The Journal of biological chemistry - 21 May 2010

Radhakrishnan Yashwanth, Busby Walker H, Shen Xinchun, Maile Laura A, Clemmons David R

Abstract excerpt

Vascular smooth muscle cells maintained in normal (5.6 mm) glucose respond to insulin-like growth factor-I (IGF-I) with increased protein synthesis but do not proliferate. In contrast, hyperglycemia alters responsiveness to IGF-I, resulting in increased SHPS-1 phosphorylation and assembly of a signaling complex that enhances MAPK and phosphatidylinositol 3-kinase pathways. Hyperglycemia also reduces the basal...

Topics

Animals
Antigens, Differentiation
Cell Line
Cell Proliferation
Glucose
Humans
Insulin Receptor Substrate Proteins
Insulin-Like Growth Factor I
MAP Kinase Signaling System
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Smooth, Vascular

Mutation

Myocytes, Smooth Muscle

Phosphorylation

Protein Binding

Protein Tyrosine Phosphatase, Non-Receptor Type 11

Rats

Receptor, IGF Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 20207740
DOI: 10.1074/jbc.M109.092270
PMCID: PMC2871434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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