Phenotypic changes in vascular smooth muscle cells during aging: insulin effect on migration.

doi:10.1159/000021999

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Article

Phenotypic changes in vascular smooth muscle cells during aging: insulin effect on migration.

Gerontology - 1 Jan 1998

Muñoz F J, Jiménez M, Melón J, Ruiz-Torres A

Abstract excerpt

We examined the mechanisms by which insulin may be atherogenic during aging. We postulated that an increase in insulin secretion during aging produces growth factor effects on vascular smooth muscle cells (VSMCs), promoting these cells to synthesize collagen and to migrate. We have previously dem...

Topics

Aged
Aging
Cell Movement
Chemotactic Factors
Collagen
Humans
Insulin
Muscle, Smooth, Vascular
Phenotype

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