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Article

Phenotypic changes in vascular smooth muscle cells during aging: insulin effect on migration.

Gerontology - 1 Jan 1998

Muñoz F J, Jiménez M, Melón J, Ruiz-Torres A

Abstract excerpt

We examined the mechanisms by which insulin may be atherogenic during aging. We postulated that an increase in insulin secretion during aging produces growth factor effects on vascular smooth muscle cells (VSMCs), promoting these cells to synthesize collagen and to migrate. We have previously demonstrated that insulin stimulates collagen synthesis and release in senescent VSMCs that were obtained from a human...

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Identifiers

PMID: 9592686
DOI: 10.1159/000021999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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