Article
Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 2002
Montagnani Monica, Ravichandran Lingamanaidu V, Chen Hui, Esposito Diana L, Quon Michael J
Abstract excerpt
Vasodilator actions of insulin are mediated by signaling pathways involving phosphatidylinositol 3-kinase (PI 3-kinase) and Akt that lead to activation of endothelial nitric oxide synthase (eNOS) in endothelium. Signaling molecules immediately upstream and downstream from PI 3-kinase involved with production of NO in response to insulin have not been previously identified. In this study, we evaluated roles of...
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