Article
Transglutaminase type II plays a protective role in hepatic injury.
The American journal of pathology - 1 Apr 2003
Nardacci Roberta, Lo Iacono Oreste, Ciccosanti Fabiola, Falasca Laura, Addesso Maria, Amendola Alessandra, Antonucci Giorgio, Craxì Antonio, Fimia Gian Maria, Iadevaia Valentina, Melino Gerry, Ruco Luigi, Tocci Guido, Ippolito Giuseppe, Piacentini Mauro
Abstract excerpt
The up-regulation of "tissue" transglutaminase (TG2) gene has been shown to occur in various pathologies and can lead to severe liver injury; however, its role in the onset of liver damage has not yet been clarified. To address this issue, we have used two experimental settings: carbon tetrachloride (CCl(4))-induced liver injury in wild-type and TG2 knockout mice; and liver biopsies obtained from a large cohort...
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