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Article

Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes # †

28 May 2009

Abstract excerpt

UNLABELLED: Connective tissue growth factor (CCN2) is a matricellular protein that is up-regulated in many fibrotic disorders and coexpressed with transforming growth factor beta. CCN2 promotes fibrogenesis and survival in activated hepatic stellate cells, and injured or fibrotic liver contains up-regulated levels of CCN2 that are produced by a variety of different cell types, including hepatocytes. To...

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PMID: 19670427
DOI: 10.1002/hep.23102

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