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Article

In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression

4 Apr 2011

Abstract excerpt

UNLABELLED: Interleukin-22 (IL-22), which acts as either a proinflammatory or anti-inflammatory cytokine in various disease models, is markedly up-regulated in chronic liver diseases, including hepatitis B and C. In this report, we demonstrate a strong correlation between IL-22 expression in the liver with active, inflammatory human liver disease. To clarify the role of IL-22 up-regulation in the pathogenesis of...

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PMID: 21465510
DOI: 10.1002/hep.24339

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