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Article

Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice.

Biochemical and biophysical research communications - 8 Aug 2008

Yu Jun, Wu Chung W, Chu Eagle S H, Hui Alex Y, Cheng Alfred S L, Go Minnie Y Y, Ching Arthur K K, Chui Yiu L, Chan Henry L Y, Sung Joseph J Y

Abstract excerpt

Hepatic COX-2 overexpression is sufficient to induce hepatitis, but its role on liver fibrosis remains unknown. We aim to elucidate possible biological effects of COX-2 in liver fibrosis using both gain-of-function and loss-of-function mouse models. COX-2 transgenic (TG) mice that specifically ov...

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Identifiers

PMID: 18503750
DOI: 10.1016/j.bbrc.2008.05.069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18503750-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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