Article
Genome imprinting regulated by the mouse Polycomb group protein Eed.
Nature genetics - 1 Apr 2003
Mager Jesse, Montgomery Nathan D, de Villena Fernando Pardo-Manuel, Magnuson Terry
Abstract excerpt
Epigenetic regulation is essential for temporal, tissue-specific and parent-of-origin-dependent gene expression. It has recently been found that the mouse Polycomb group (PcG) gene Eed (embryonic ectoderm development) acts to maintain repression of the imprinted X chromosome. Here, we investigated whether Eed is also required for regulation of autosomal imprinted loci. Expression analyses showed that transcripts...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.