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Article

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.

Molecular cell - 2 Jul 2004

Cao Ru, Zhang Yi

Abstract excerpt

Recent studies have revealed the intrinsic histone methyltransferase (HMTase) activity of the EED-EZH2 complex and its role in Hox gene silencing, X inactivation, and cancer metastasis. In this study, we focus on the function of individual components. We found that the HMTase activity requires a minimum of three components-EZH2, EED, and SUZ12-while AEBP2 is required for optimal enzymatic activity. Using a stable...

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Share to Enhancer of Zeste Homolog 2 Protein
Share to Genes, Homeobox
Share to Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Polycomb Repressive Complex 2

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Source

Identifiers

PMID: 15225548
DOI: 10.1016/j.molcel.2004.06.020

Genes

SUZ12
EED
AEBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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