A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.

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Article

A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.

Cancer research - 1 Nov 1996

Chen J, Giovannucci E, Kelsey K, Rimm E B, Stampfer M J, Colditz G A, Spiegelman D, Willett W C, Hunter D J

Abstract excerpt

We examined the relationship of a common polymorphism (667C-->T) of the methylenetetrahydrofolate reductase (MTHFR) gene with the risk of colorectal cancer in a case-control study conducted in the Health Professionals Follow-up Study. MTHFR genotypes were ascertained from blood samples among 144...

Topics

Adult
Aged
Colorectal Neoplasms
Ethanol
Folic Acid
Genotype
Humans
Male
Methionine
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Oxidoreductases Acting on CH-NH Group Donors
Polymorphism, Genetic
Prospective Studies
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 8895734

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8895734-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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