Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of polymorphisms on the replicative capacity of protease inhibitor-resistant HIV-1 variants under drug pressure.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Feb 2004

Suñé C, Brennan L, Stover D R, Klimkait T

Abstract excerpt

The role of drug pressure on the replicative capacity of protease inhibitor-resistant HIV-1 variants and the contribution of a common amino-acid polymorphism in the protease gene (L63P) to this process were investigated. Using HIV-1 variants resistant to the protease inhibitors saquinavir (G48V/L90M) or indinavir (A71V/V82T/I84V), viral replication was studied in the presence or absence of inhibitor and a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to HIV Protease

Share to HIV Protease Inhibitors

Share to Sequence Analysis, DNA

Share to Virus Replication

Source

Identifiers

PMID: 14759236
DOI: 10.1111/j.1469-0691.2004.00832.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of polymorphisms on the replicative capacity of protease inhibitor-resistant HIV-1 variants under drug pressure.PMID 14759236Read ↗

Processivity and drug-dependence of HIV-1 protease: determinants of viral fitness in variants resistant to protease inhibitors.Semantic proximity Read ↗

HIV-1 evolution under pressure of protease inhibitors: climbing the stairs of viral fitness.Semantic proximity Read ↗

The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients.Semantic proximity Read ↗

Impact on replicative fitness of the G48E substitution in the protease of HIV-1: an in vitro and in silico evaluation.Semantic proximity Read ↗

Fitness of human immunodeficiency virus type 1 protease inhibitor-selected single mutants.Semantic proximity Read ↗

Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis.Semantic proximity Read ↗

Variant human immunodeficiency virus type 1 proteases and response to combination therapy including a protease inhibitor.Semantic proximity Read ↗

Replicative Fitness of Protease Inhibitor-Resistant Mutants of Human Immunodeficiency Virus Type 1Semantic proximity Read ↗

Retracing the Evolutionary Pathways of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors: Virus Fitness in the Absence and in the Presence of DrugSemantic proximity Read ↗

Emergence of resistant variants of HIV in vivo during monotherapy with the proteinase inhibitor saquinavir.Semantic proximity Read ↗

Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults.Semantic proximity Read ↗

The HIV Type 1 Protease L10I Minor Mutation Decreases Replication Capacity and Confers Resistance to Protease InhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.