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Article

Gag mutations strongly contribute to HIV-1 resistance to protease inhibitors in highly drug-experienced patients besides compensating for fitness loss.

PLoS pathogens - 1 Mar 2009

Dam Elisabeth, Quercia Romina, Glass Bärbel, Descamps Diane, Launay Odile, Duval Xavier, Kräusslich Hans-Georg, Hance Allan J, Clavel François

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) resistance to protease inhibitors (PI) results from mutations in the viral protease (PR) that reduce PI binding but also decrease viral replicative capacity (RC). Additional mutations compensating for the RC loss subsequently accumulate within PR and in Gag substrate cleavage sites. We examined the respective contribution of mutations in PR and Gag to PI resistance and...

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Share to Drug Resistance, Viral
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Peptide Hydrolases

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Share to Protease Inhibitors

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Source

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Identifiers

PMID: 19300491
DOI: 10.1371/journal.ppat.1000345
PMCID: PMC2652074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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