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Article

Binge eating as a major phenotype of melanocortin 4 receptor gene mutations.

The New England journal of medicine - 20 Mar 2003

Branson Ruth, Potoczna Natascha, Kral John G, Lentes Klaus-Ulrich, Hoehe Margret R, Horber Fritz F

Abstract excerpt

BACKGROUND: Obesity, a multifactorial disease caused by the interaction of genetic factors with the environment, is largely polygenic. A few mutations in these genes, such as in the leptin receptor (LEPR) gene and melanocortin 4 receptor (MC4R) gene, have been identified as causes of monogenic obesity. METHODS: We sequenced the complete MC4R coding region, the region of the proopiomelanocortin gene (POMC)...

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Source

Identifiers

PMID: 12646666
DOI: 10.1056/NEJMoa021971

Genes

LEPR
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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