Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Melanocortin pathways: suppressed and stimulated melanocortin-4 receptor (MC4R).

Physiological research - 30 Sept 2020

Hainer V, Aldhoon Hainerová I, Kunešová M, Taxová Braunerová R, Zamrazilová H, Bendlová B

Abstract excerpt

Leptin-melanocortin pathway plays an essential role in the body weight regulation. Enhanced melanocortin signaling in the hypothalamus results in both decreased food intake and increased energy expenditure. The discovery of monogenic obesities with dysfunction of melanocortin-4 receptor (MC4R) greatly contributed to understanding of energy balance regulation. This review presents phenotypical characterization and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Obesity
Share to alpha-MSH

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biochemical Analysis and Sensing Techniques

Share to Genome-Wide Association Study

Share to Molecular Targeted Therapy

Share to Receptor, Melanocortin, Type 4

Share to Regulation of Appetite and Obesity

Source

Open in PubMed Open full text

Identifiers

PMID: 33094623
DOI: 10.33549/physiolres.934512
PMCID: PMC8603737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Melanocortin pathways: suppressed and stimulated melanocortin-4 receptor (MC4R).PMID 33094623Read ↗

MC4R in Central and Peripheral SystemsSemantic proximity Read ↗

The central melanocortin system and human obesity.Semantic proximity Read ↗

The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options.Semantic proximity Read ↗

Melanocortin 4 receptor mutation in obesitySemantic proximity Read ↗

Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis.Semantic proximity Read ↗

Rare genetic forms of obesity: From gene to therapy.Semantic proximity Read ↗

The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Semantic proximity Read ↗

Rare Genetic Forms of Obesity: Clinical Approach and Current Treatments in 2016.Semantic proximity Read ↗

MECHANISMS IN ENDOCRINOLOGY: Update on treatments for patients with genetic obesity.Semantic proximity Read ↗

Updates on Monogenic Obesity in a Multifactorial Disease.Semantic proximity Read ↗

Biased signaling at neural melanocortin receptors in regulation of energy homeostasis.Semantic proximity Read ↗

Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.