Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review.

doi:10.1038/ijo.2012.169

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Article

Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review.

International journal of obesity (2005) - 1 Aug 2013

Valette M, Bellisle F, Carette C, Poitou C, Dubern B, Paradis G, Hercberg S, Muzard L, Clément K, Czernichow S

Abstract excerpt

Melanocortin-4 receptor (MC4R) mutations are the most common known cause of monogenic obesity and an important contributor to polygenic obesity. MC4R mutations with partial or total loss of function, as well as the variant rs17782313 mapped near MC4R, are positively associated with obesity. MC4R is involved in the leptin-melanocortin signalling system, located in hypothalamic nuclei, that controls food intake via...

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PMID: 23147118
DOI: 10.1038/ijo.2012.169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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