Article
Association between melanocortin-4 receptor mutations and eating behaviors in obese patients: a case--control study.
International journal of obesity (2005) - 1 Jun 2014
Valette M, Poitou C, Kesse-Guyot E, Bellisle F, Carette C, Le Beyec J, Hercberg S, Clément K, Czernichow S
Abstract excerpt
Melanocortin-4 receptor (MC4R) gene mutations are involved in the leptin-melanocortin pathways that control food intake. The effect of these mutations on eating behavior phenotypes is still debated. To determine the association between functional MC4R mutations and eating behaviors, dietary intake and physical activity, we sequenced the MC4R gene in 4653 obese adults. Among them, 19 adults carriers of functional...
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