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Article

Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract - 1 Dec 2004

Potoczna Natascha, Branson Ruth, Kral John G, Piec Grazyna, Steffen Rudolf, Ricklin Thomas, Hoehe Margret R, Lentes Klaus-Ulrich, Horber Fritz F

Abstract excerpt

Melanocortin-4 receptor gene (MC4R) variants are associated with obesity and binge eating disorder (BED), whereas the more prevalent proopiomelanocortin (POMC) and leptin receptor gene (LEPR) mutations are rarely associated with obesity or BED. The complete coding regions of MC4R, POMC, and leptin-binding domain of LEPR were comparatively sequenced in 300 patients (233 women and 67 men; mean +/- SEM age, 42 +/- 1...

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Share to Body Composition
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metabolic Syndrome

Share to Obesity, Morbid

Share to Pro-Opiomelanocortin

Share to Receptor, Melanocortin, Type 4

Share to Receptors, Leptin

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Source

Identifiers

PMID: 15585384
DOI: 10.1016/j.gassur.2004.09.032

Genes

LEPR
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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