Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic beta cells.

Journal of cell science - 15 Apr 2003

Haefliger Jacques-Antoine, Tawadros Thomas, Meylan Laure, Gurun Sabine Le, Roehrich Marc-Estienne, Martin David, Thorens Bernard, Waeber Gérard

Abstract excerpt

In insulin-secreting cells, cytokines activate the c-Jun N-terminal kinase (JNK), which contributes to a cell signaling towards apoptosis. The JNK activation requires the presence of the murine scaffold protein JNK-interacting protein 1 (JIP-1) or human Islet-brain 1(IB1), which organizes MLK3, MKK7 and JNK for proper signaling specificity. Here, we used adenovirus-mediated gene transfer to modulate IB1/JIP-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Fragmentation
Share to Interferon-gamma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1

Share to Islets of Langerhans

Share to JNK Mitogen-Activated Protein Kinases

Share to Mitogen-Activated Protein Kinases

Share to Rats, Wistar

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 12640031
DOI: 10.1242/jcs.00356

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic beta cells.PMID 12640031Read ↗

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta CellsSemantic proximity Read ↗

Expression of JNK interacting protein JIP-1 is down-regulated in liver from mouse embryos with a disrupted insulin-like growth factor II gene.Semantic proximity Read ↗

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes.Semantic proximity Read ↗

Evidence of Contribution of iPLA2β-Mediated Events During Islet β-Cell Apoptosis Due to Proinflammatory Cytokines Suggests a Role for iPLA2β in T1D DevelopmentSemantic proximity Read ↗

The role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice.Semantic proximity Read ↗

Bromodomain protein inhibition protects β-cells from cytokine-induced death and dysfunction via antagonism of NF-κB pathwaySemantic proximity Read ↗

Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease.Semantic proximity Read ↗

Circadian desynchronization desensitizes insulin-producing cells to cytokine-mediated transcriptomic remodeling and cell death: a novel beta-cell anti-apoptotic response to inflammationSemantic proximity Read ↗

p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress.Semantic proximity Read ↗

IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation.Semantic proximity Read ↗

Differential effect of ik3-1/cables on p53- and p73-induced cell death.Semantic proximity Read ↗

Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.