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Article

Differential effect of ik3-1/cables on p53- and p73-induced cell death.

The Journal of biological chemistry - 25 Jan 2002

Tsuji Keitaro, Mizumoto Kiyohisa, Yamochi Tadanori, Nishimoto Ikuo, Matsuoka Masaaki

Abstract excerpt

ik3-1/Cables is associated with cdk3 in self-replicating cells. In postmitotic neurons, it may serve as an adaptor molecule, functionally connecting c-abl and cdk5, and supporting neurite growth. Here we report that ik3-1 binds to p53 and p73 in vivo. Ectopically expressed ik3-1 potentiates p53-induced cell death but not p73-induced cell death in U2OS cells. On the contrary, coexpression of ik3-1-DeltaC, an ik3-1...

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PMID: 11706030
DOI: 10.1074/jbc.M108535200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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