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Article

Inhibition of protein kinase C by synthetic xanthone derivatives.

Bioorganic & medicinal chemistry - 3 Apr 2003

Saraiva Lucília, Fresco Paula, Pinto Eugénia, Sousa Emília, Pinto Madalena, Gonçalves Jorge

Abstract excerpt

The modulatory activity of two xanthones (3,4-dihydroxyxanthone and 1-formyl-4-hydroxy-3-methoxyxanthone) on isoforms alpha, betaI, delta, eta and zeta of protein kinase C (PKC) was evaluated using an in vivo yeast phenotypic assay. Both xanthones caused an effect compatible with PKC inhibition, similar to that elicited by known PKC inhibitors (chelerythrine and NPC 15437). PKC inhibition caused by xanthones was...

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Identifiers

PMID: 12628649
DOI: 10.1016/s0968-0896(02)00641-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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