Article
Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study.
Biochemistry - 12 Oct 2004
Meggio Flavio, Pagano Mario A, Moro Stefano, Zagotto Giuseppe, Ruzzene Maria, Sarno Stefania, Cozza Giorgio, Bain Jenny, Elliott Matthew, Deana Arianna Donella, Brunati Anna Maria, Pinna Lorenzo A
Abstract excerpt
ATP site-directed inhibitors that can target individual kinases are powerful tools for use in signal transduction research, all the more so in the case of a pleiotropic, constitutively active protein kinase such as CK2, which is not turned on in response to specific stimuli. By screening a library of more than 200 derivatives of natural polyphenolic compounds, we have identified 16 molecules which inhibit CK2...
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