Article
Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2003
Skol A D, Young K A, Tsuang D W, Faraone S V, Haverstock S L, Bingham S, Prabhudesai S, Mena F, Menon A S, Yu Chang-En, Rundell Paul, Pepple J, Sauter F, Baldwin C, Weiss D, Collins J, Keith T, Boehnke M, Schellenberg G D, Tsuang M T
Abstract excerpt
Wei and Hemmings [2000: Nat Genet 25:376-377], using 80 British parent-offspring trios, identified a number of NOTCH4 variants and haplotypes that showed statistically significant evidence of association to schizophrenia. Specifically, the 10 repeat allele of a (CTG)(n) marker and the 8 repeat allele of a (TAA)(n) marker demonstrated excess transmission to affected individuals; SNP21 and haplotypes SNP2-(CTG)(n)...
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