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Article

NOTCH4 gene haplotype is associated with schizophrenia in African Americans.

Biological psychiatry - 15 Jan 2004

Luo Xingguang, Klempan Tim A, Lappalainen Jaakko, Rosenheck Robert A, Charney Dennis S, Erdos Joseph, van Kammen Daniel P, Kranzler Henry R, Kennedy James L, Gelernter Joel

Abstract excerpt

BACKGROUND: The goal of this study was to investigate the relationship between the NOTCH4 gene and schizophrenia in African American (AA) and European American (EA) subjects. METHODS: Two single nucleotide polymorphisms (SNPs) at the NOTCH4 locus were genotyped in 123 AA schizophrenia patients, 223 EA schizophrenia patients, 85 AA healthy control subjects, and 211 EA healthy control subjects. The specific markers...

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Source

Identifiers

PMID: 14732589
DOI: 10.1016/s0006-3223(03)00588-2

Genes

NOTCH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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NOTCH4 gene haplotype is associated with schizophrenia in African Americans.PMID 14732589Read ↗

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The NOTCH4 locus is associated with susceptibility to schizophrenia.Semantic proximity Read ↗

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Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene.Semantic proximity Read ↗

No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis.Semantic proximity Read ↗

A review and re-evaluation of an association between the NOTCH4 locus and schizophrenia.Semantic proximity Read ↗

Five NOTCH4 polymorphisms show weak evidence for association with schizophrenia: evidence from meta-analyses.Semantic proximity Read ↗

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Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and UgandaSemantic proximity Read ↗

A family-based and case-control association study of the NOTCH4 gene and schizophrenia.Semantic proximity Read ↗

NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees.Semantic proximity Read ↗

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