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Article

Structural insights into the U-box, a domain associated with multi-ubiquitination.

Nature structural biology - 1 Apr 2003

Ohi Melanie D, Vander Kooi Craig W, Rosenberg Joshua A, Chazin Walter J, Gould Kathleen L

Abstract excerpt

The structure of the U-box in the essential Saccharomyces cerevisiae pre-mRNA splicing factor Prp19p has been determined by NMR. The conserved zinc-binding sites supporting the cross-brace arrangement in RING-finger domains are replaced by hydrogen-bonding networks in the U-box. These hydrogen-bonding networks are necessary for the structural stabilization and activity of the U-box. A conservative Val-->Ile point...

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Source

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Identifiers

PMID: 12627222
DOI: 10.1038/nsb906
PMCID: PMC5881891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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