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Article

Structural and functional analysis of essential pre-mRNA splicing factor Prp19p.

Molecular and cellular biology - 1 Jan 2005

Ohi Melanie D, Vander Kooi Craig W, Rosenberg Joshua A, Ren Liping, Hirsch Justin P, Chazin Walter J, Walz Thomas, Gould Kathleen L

Abstract excerpt

U-box-containing Prp19p is an integral component of the Prp19p-associated complex (the nineteen complex, or NTC) that is essential for activation of the spliceosome. Prp19p makes numerous protein-protein contacts with other NTC components and is required for NTC stability. Here we show that Prp19p forms a tetramer in vitro and in vivo and we map the domain required for its oligomerization to a central tetrameric...

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Source

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Identifiers

PMID: 15601865
DOI: 10.1128/MCB.25.1.451-460.2005
PMCID: PMC538785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural and functional analysis of essential pre-mRNA splicing factor Prp19p.PMID 15601865Read ↗

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Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p.Semantic proximity Read ↗

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