Article
Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione. Expression studies in Xenopus laevis oocytes.
The Journal of biological chemistry - 7 Jul 1995
García-Ruiz C, Morales A, Colell A, Rodés J, Yi J R, Kaplowitz N, Fernández-Checa J C
Abstract excerpt
Mitochondrial GSH derives from a mitochondrial transport system (RmGshT), which translocates cytosol GSH into the mitochondrial matrix. Mitochondria of oocytes, isolated 3-4 days after microinjection of total liver mRNA, expressed a RmGshT compared with water-injected oocytes. The expressed RmGsh...
Topics
- Animals
- Bile Canaliculi
- Biological Transport
- Carrier Proteins
- Cell Fractionation
- Female
- Genetic Variation
- Glutathione
- Liver
- Male
- Membrane Transport Proteins
- Microinjections
- Mitochondria, Liver
- Oocytes