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Article

Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1).

The Journal of biological chemistry - 6 Apr 2001

Neve E P, Ingelman-Sundberg M

Abstract excerpt

Cytochrome P450 2E1 (CYP2E1) lacking the hydrophobic NH(2)-terminal hydrophobic transmembrane domain is specifically targeted to mitochondria, where it is processed to a soluble and catalytically active form (Delta2E1) with a mass of about 40 kDa. Small amounts of Delta2E1 were also observed in mitochondria isolated from rat liver, indicating that this form of CYP2E1 is also present in vivo. In the present study...

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Source

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PMID: 11133991
DOI: 10.1074/jbc.M008640200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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