Article
Use of lymphocytes for assessing ethanol-mediated alterations in the expression of hepatic cytochrome P4502E1.
Alcoholism, clinical and experimental research - 1 Dec 1995
Raucy J L, Curley G, Carpenter S P
Abstract excerpt
The ethanol-inducible cytochrome P4502E1 (2E1) is involved in the bioactivation of numerous hepatotoxins and hepatocarcinogens. Because high levels of expression may enhance the degree and severity of hepatotoxicity from exposure to chemicals metabolized by this enzyme, a relatively noninvasive m...
Topics
- Alcoholism
- Animals
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Enzyme Induction
- Ethanol
- Gene Expression Regulation, Enzymologic
- Genetic Markers
- Lymphocytes
- Microsomes, Liver
- Oxidoreductases, N-Demethylating
- Phenotype
- Rabbits